Are you talking about a single ESXi host with local disks ?
Then the answer is easy:
NEVER even consider using a standalone ESXi with just one VMFS-volume.
It may look like a good idea to add all disks into one large array configured with Raid5 - but resist the temptation.
When that datastore needs maintenance one day - after the next thunderstorm or the next Raid-rebuild after a diskfailure - you will regret it.
So configure a standalone host so that you have at least 2 datastores and that none of them is so large that you could not evacuate all important VMs over night.
My suggestion - not optimized for performance but for simple survival is to use datastores upto lets say 2TB and to avoid Raid5 at all costs.
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Re: Multiple Drives: 1 Large Array vs 2 Smaller Arrays
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