Hi David,
What I mean is: If I remove access through our storage management, the ESXi server will not have a clue why the storage disappeared. Hence it will start generating errors etc. - just like when you remove the zoning.
I believe the "correct" way of removing the storage is thorugh vCenter somehow. I might be wrong though, but according to this article, simply removing access to datastores without the ESXi server "knowing" about it, will cause troubles...:
/Rasmus