Hardware adapters are always going to perform better due to the offloading. BUT I would not mix and match as in if there is only a couple of hosts in a cluster with hardware then use software. as long as its consistent across hosts in the cluster. Its not that its not supported to run some hosts with hardware adapters and some with software, it comes down to support least if you have a problem all the hosts are consistent and makes pinpointing issues allot more easier.
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