Setting MultiPathing Policies on a per-LUN basis

I have one VM per cluster that needs a fixed multipathing policy to access an RDM as per vendor requirements.  The other VMs would normally be using round-robin as per best practices

http://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=2034797

I need this VM to be able to be protected by HA, so that all hosts in a cluster should be able to access the RDM using a fixed multipathing policy.  But all other datastore access should use round robin.

Is this possible and are there any caviats / gotchas?