Of course you can do it! Just a few options:
1) You should use cluster-aware file system to format the volume. GlusterFS, OCFS2, VMFS, SFS, MelioFS etc. They keep a
2) Using non-cluster aware file system would require you to use an external distributed lock. For say NTFS and HFS you can use MetaSAN from Tiger Technologies.
3) Use cluster-aware application doing arbitration on it's own. Say Hyper-V will keep one node access in a block mode to NTFS and other nodes will have redirected
access thru the SMB file share (mix of the block and file access). VMware has clustered file system (VMFS) and Microsoft still is playing games with a good old NTFS 
Generally speaking the topic raises since FC and shared parallel SCSI all the time. You can read more there:
Trying to be clear on this - use iSCSI instead of SMB
(StarWind discussion forum but the topic itself has nothing to do with the company itself, it's the same for all the SANs) and here:
http://community.spiceworks.com/topic/376034-multi-hyper-v-host-sharing-one-storage-volume
(also about Hyper-V in general but the topic is the same including all the concepts and options).
Good luck
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Hi there,
i'm running into a problem with my Synology DiskStation and vSphere 5.1.
I created a LUN on my Synology and set up an iSCSI Target with multiple connections allowed!
While having only one ESXi host connected it runs fine. As soon as i connect a second host i'll get "Failed to log into NFC Server".
I double cheked all the recommendations from this forum (for example DNS, the well known KB to fix this problem,...) - nothing help.
If i disconnect the host and run just a single connection to the fileserver it's fine again...
I read a hint on the synology box "Be sure to run a cluster filesystem on your device while allowing multi connections..."
But a iSCSI-datastore is VMFS and that is a cluster fs, isn't it?
May be a stupid question but it's my first lab build with an ESXi-Cluster and a dedicated Fileserver...